| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RPH3A |
| Gene ID: | 22895 |
| Uniprot ID: | RP3A_HUMAN |
| Immunogen Region: | 1-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human RPH3A (NP_055769.2). |
| Immunogen Sequence: | MTDTVFSNSSNRWMYPSDRP LQSKLQAGWSVHPGGQPDRQ RKQEELTDEEKEIINRVIAR AEKMEEMEQERIGRLVDRLE NMRKNVAGDGVNRCILCGEQ LGMLGSACVVCEDCKKNVCT KCGVETNNRLHSVWLCKICI EQREVWKRSGAWFFKGFPKQ VLPQPMPIKKTKPQQPVSEP AAPEQPAPEPKHPARAPARG DSEDRRGPGQKTGPDPASAP GRGNYGPPVRRASEARMSS |
| Post Translational Modifications | Ubiquitinated. Deubiquitinated by CAND1 to prevent its degradation. |
| Function | Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone. |
| Protein Name | Rabphilin-3aExophilin-1 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneCell ProjectionDendritic SpinePostsynaptic Cell MembraneMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Rabphilin-3a antibodyAnti-Exophilin-1 antibodyAnti-RPH3A antibodyAnti-KIAA0985 antibody |
Information sourced from Uniprot.org
