| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RPGR |
| Gene ID: | 6103 |
| Uniprot ID: | RPGR_HUMAN |
| Immunogen Region: | 1-260 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human RPGR (NP_001030025.1). |
| Immunogen Sequence: | MREPEELMPDSGAVFTFGKS KFAENNPGKFWFKNDVPVHL SCGDEHSAVVTGNNKLYMFG SNNWGQLGLGSKSAISKPTC VKALKPEKVKLAACGRNHTL VSTEGGNVYATGGNNEGQLG LGDTEERNTFHVISFFTSEH KIKQLSAGSNTSAALTEDGR LFMWGDNSEGQIGLKNVSNV CVPQQVTIGKPVSWISCGYY HSAFVTTDGELYVFGEPENG KLGLPNQLLGNHRTPQLVS |
| Tissue Specificity | Heart, brain, placenta, lung, liver, muscle, kidney, retina, pancreas and fetal retinal pigment epithelium. Isoform 3 is found only in the retina. Colocalizes with RPGRIP1 in the outer segment of rod photoreceptors and cone outer segments. |
| Post Translational Modifications | Prenylated. |
| Function | Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes. May be involved in microtubule organization and regulation of transport in primary cilia. |
| Protein Name | X-Linked Retinitis Pigmentosa Gtpase Regulator |
| Cellular Localisation | Cytoplasm Cytoskeleton Flagellum Axoneme Golgi Apparatus Cell Projection Cilium In The Retinal Photoreceptor Cell Layer Localizes At The Connecting Cilium Colocalizes With Whrn In The Photoreceptor Connecting Cilium Colocalizes With Cep290 In The Photoreceptor Connecting Cilium Colocalizes With Rpgrip1 In The Photoreceptor Connecting Cilium Isoform 6: Cytoplasm Microtubule Organizing Center Centrosome Cilium Basal Body Cilium Axoneme |
| Alternative Antibody Names | Anti-X-Linked Retinitis Pigmentosa Gtpase Regulator antibody Anti-RPGR antibody Anti-RP3 antibody Anti-XLRP3 antibody |
Information sourced from Uniprot.org