| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-RPA-interacting protein (117-167 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RPAIN |
| Gene ID: | 84268 |
| Uniprot ID: | RIP_HUMAN |
| Immunogen Region: | 117-167 aa |
| Specificity: | This antibody detects endogenous levels of RIP at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human RIP at the amino acid range 117-167 |
| Post Translational Modifications | Isoform 2: Sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues. Variant 'Lys-103' adds a sumoylation site and increases total sumoylation levels. |
| Function | Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism. |
| Protein Name | Rpa-Interacting ProteinHrip |
| Cellular Localisation | Isoform 1: CytoplasmNucleusIsoform 2: NucleusPml Body |
| Alternative Antibody Names | Anti-Rpa-Interacting Protein antibodyAnti-Hrip antibodyAnti-RPAIN antibodyAnti-RIP antibody |
Information sourced from Uniprot.org