Anti-RORB antibody [R01-2W3] (STJA0037135)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human ROR beta
General Information
| Short Description | Rabbit monoclonal anti-RORB for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-2W3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | RORB |
| Gene ID | 6096 |
| Uniprot ID | RORB_HUMAN |
| Immunogen | A synthesized peptide derived from human ROR beta |
Additional Info
| Function | Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity. Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4. |
| Protein Name | Nuclear Receptor Ror-BetaNuclear Receptor Rzr-BetaNuclear Receptor Subfamily 1 Group F Member 2Retinoid-Related Orphan Receptor-Beta |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | NucleusNucleoplasm |
| Alternative Antibody Names | Anti-Nuclear Receptor Ror-Beta antibodyAnti-Nuclear Receptor Rzr-Beta antibodyAnti-Nuclear Receptor Subfamily 1 Group F Member 2 antibodyAnti-Retinoid-Related Orphan Receptor-Beta antibodyAnti-RORB antibodyAnti-NR1F2 antibodyAnti-RZRB antibody |
Information sourced from Uniprot.org