| Function | Receptor involved in axon guidance during development. Acts as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits SLIT repulsion, and facilitates Netrin-1/NTN1 attraction. In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1/ROBO2. Binding OF NELL2 to the receptor ROBO3 promotes oligomerization of ROBO3, resulting in the repulsion of commissural axons in the midline. ROBO3 also indirectly boosts axon attraction to NTN1 without interacting with NTN1 itself. Isoform 1: Mediates NELL2 premature repulsion of commissural axons during midline crossing. Isoform 2: After midline crossing by the commissural axons, may, in concert with ROBO1 and ROBO2, prevent midline recrossing. Does not mediate NELL2 signaling. |
| Protein Name | Roundabout Homolog 3Retinoblastoma-Inhibiting Gene 1 ProteinRig-1Roundabout Guidance Receptor 3 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Roundabout Homolog 3 antibodyAnti-Retinoblastoma-Inhibiting Gene 1 Protein antibodyAnti-Rig-1 antibodyAnti-Roundabout Guidance Receptor 3 antibodyAnti-Robo3 antibodyAnti-Rbig1 antibody |
Information sourced from Uniprot.org
