| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RNF7 (1-113) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:20-1:50 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RNF7 |
| Gene ID: |
9616 |
| Uniprot ID: |
RBX2_HUMAN |
| Immunogen Region: |
1-113 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-113 of human RNF7 (NP_055060.1). |
| Immunogen Sequence: |
MADVEDGEETCALASHSGSS GSKSGGDKMFSLKKWNAVAM WSWDVECDTCAICRVQVMDA CLRCQAENKQEDCVVVWGEC NHSFHNCCMSLWVKQNNRCP LCQQDWVVQRIGK |
| Tissue Specificity | Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung. |
| Post Translational Modifications | Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B. |
| Function | Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. |
| Protein Name | Ring-Box Protein 2Rbx2Ckii Beta-Binding Protein 1Ckbbp1Ring Finger Protein 7Regulator Of Cullins 2Sensitive To Apoptosis Gene Protein |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-9705462Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ring-Box Protein 2 antibodyAnti-Rbx2 antibodyAnti-Ckii Beta-Binding Protein 1 antibodyAnti-Ckbbp1 antibodyAnti-Ring Finger Protein 7 antibodyAnti-Regulator Of Cullins 2 antibodyAnti-Sensitive To Apoptosis Gene Protein antibodyAnti-RNF7 antibodyAnti-RBX2 antibodyAnti-ROC2 antibodyAnti-SAG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
