| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase RNF19B (272-322 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RNF19B |
| Gene ID: | 127544 |
| Uniprot ID: | RN19B_HUMAN |
| Immunogen Region: | 272-322 aa |
| Specificity: | This antibody detects endogenous levels of human RN19B |
| Immunogen: | Synthesized peptide derived from the human RN19B at the amino acid range 272-322 |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf19bIbr Domain-Containing Protein 3Natural Killer Lytic-Associated MoleculeRing Finger Protein 19b |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasmic Granule MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf19b antibodyAnti-Ibr Domain-Containing Protein 3 antibodyAnti-Natural Killer Lytic-Associated Molecule antibodyAnti-Ring Finger Protein 19b antibodyAnti-RNF19B antibodyAnti-IBRDC3 antibodyAnti-NKLAM antibody |
Information sourced from Uniprot.org