| Tissue Specificity | Ubiquitously expressed. |
| Function | E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS at 'Lys-173' and 'Lys-384', thereby promoting CGAS cyclic GMP-AMP synthase activity. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf185Ring Finger Protein 185 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5678895Reactome: R-HSA-901032 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf185 antibodyAnti-Ring Finger Protein 185 antibodyAnti-RNF185 antibody |
Information sourced from Uniprot.org
