Anti-RNF170 antibody (STJA0009158)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human RNF170
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase RNF170 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RNF170 |
| Gene ID | 81790 |
| Uniprot ID | RN170_HUMAN |
| Immunogen | Synthesized peptide derived from human RNF170 |
| Specificity | This antibody detects endogenous levels of RNF170 at Human, Mouse |
Additional Info
| Function | E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Selectively inhibits the TLR3-triggered innate immune response by promoting the 'Lys-48'-linked polyubiquitination and degradation of TLR3. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf170Putative Lag1-Interacting ProteinRing Finger Protein 170Ring-Type E3 Ubiquitin Transferase Rnf170 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf170 antibodyAnti-Putative Lag1-Interacting Protein antibodyAnti-Ring Finger Protein 170 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf170 antibodyAnti-RNF170 antibody |
Information sourced from Uniprot.org