| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome (Probable). |
| Function | E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB. Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling. Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf152Ring Finger Protein 152Ring-Type E3 Ubiquitin Transferase Rnf152 |
| Database Links | Reactome: R-HSA-8866654 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf152 antibodyAnti-Ring Finger Protein 152 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf152 antibodyAnti-RNF152 antibody |
Information sourced from Uniprot.org
