| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. Plays a crucial role in maintaining the genomic stability by controlling the degradation of multiple proteins involved in mitotic progression and DNA damage. Regulates epithelial homeostasis by mediating degradation of CDKN1A and isoform 2 of TP63. Plays a regulatory role in innate immunity by negatively regulating IRF3 activation and IFN-beta production. Mechanistically, inhibits TBK1 phosphorylation and 'Lys-63'-linked polyubiquitination independently of its E3 ligase activity. Alternatively, promotes 'Lys-27' and 'Lys-33'-linked ubiquitination of IFIH1/MDA5, promoting selective autophagic degradation of IFIH1/MDA5 to inhibit antiviral response. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf144bIbr Domain-Containing Protein 2Ring Finger Protein 144bP53-Inducible Ring Finger Protein |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Mitochondrion MembraneSingle-Pass Membrane ProteinCytoplasmMostly CytosololicAccumulates In Submitochondrial Domains Specifically Upon Apoptosis InductionIn Synchrony With Bax Activation |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf144b antibodyAnti-Ibr Domain-Containing Protein 2 antibodyAnti-Ring Finger Protein 144b antibodyAnti-P53-Inducible Ring Finger Protein antibodyAnti-RNF144B antibodyAnti-IBRDC2 antibodyAnti-P53RFP antibody |
Information sourced from Uniprot.org
