| Post Translational Modifications | Auto-ubiquitinated. Controls the development of T-cell clonal anergy by ubiquitination. |
| Function | E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm.sensitizes ectoderm to respond to neural-inducing signals. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf128Gene Related To Anergy In Lymphocytes ProteinGrailRing Finger Protein 128Ring-Type E3 Ubiquitin Transferase Rnf128 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-5689896 |
| Cellular Localisation | Endomembrane SystemSingle-Pass Membrane ProteinCytoplasmCytoskeletonPerinuclear RegionLocalized In An Asymmetric Perinuclear Punctate MannerLocalizes To The Internal Pool Of The Transferrin Recycling Endosomal PathwayPartially Colocalized With The Endoplasmic Reticulum Resident Hspa5With Golgi Resident Stx5And With The Late Endosomal Gtpase Rab7a |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf128 antibodyAnti-Gene Related To Anergy In Lymphocytes Protein antibodyAnti-Grail antibodyAnti-Ring Finger Protein 128 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf128 antibodyAnti-RNF128 antibody |
Information sourced from Uniprot.org
