| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RNF115 (30-140) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RNF115 |
| Gene ID: |
27246 |
| Uniprot ID: |
RN115_HUMAN |
| Immunogen Region: |
30-140 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 30-140 of human RNF115 (NP_055270.1). |
| Immunogen Sequence: |
SPKLPEYICPRCESGFIEEV TDDSSFLGGGGSRIDNTTTT HFAELWGHLDHTMFFQDFRP FLSSSPLDQDNRANERGHQT HTDFWGARPPRLPLGRRYRS RGSSRPDRSPA |
| Tissue Specificity | Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells. |
| Post Translational Modifications | RING-type zinc finger-dependent and E2-dependent autoubiquitination. |
| Function | E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf115Ring Finger Protein 115Ring-Type E3 Ubiquitin Transferase Rnf115Rab7-Interacting Ring Finger ProteinRabring 7Zinc Finger Protein 364 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytosolThe Gtp-Bound Form Of Rab7a Recruits Rnf115 From The Cytosol Onto Late Endosomes/Lysosomes |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf115 antibodyAnti-Ring Finger Protein 115 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf115 antibodyAnti-Rab7-Interacting Ring Finger Protein antibodyAnti-Rabring 7 antibodyAnti-Zinc Finger Protein 364 antibodyAnti-RNF115 antibodyAnti-ZNF364 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
