| Tissue Specificity | Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis. |
| Post Translational Modifications | Autoubiquitinated. Polyubiquitinated in the presence of E2 enzymes UBE2D1, UBE2D2 and UBE2D3, but only monoubiquitinated in the presence of UBE2E1. |
| Function | E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as a negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation. Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C. This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf114Ring Finger Protein 114Ring-Type E3 Ubiquitin Transferase Rnf114Zinc Finger Protein 228Zinc Finger Protein 313 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf114 antibodyAnti-Ring Finger Protein 114 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf114 antibodyAnti-Zinc Finger Protein 228 antibodyAnti-Zinc Finger Protein 313 antibodyAnti-RNF114 antibodyAnti-ZNF228 antibodyAnti-ZNF313 antibody |
Information sourced from Uniprot.org
