| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RNF10 |
| Gene ID: | 9921 |
| Uniprot ID: | RNF10_HUMAN |
| Immunogen Region: | 552-811 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 552-811 of human RNF10 (NP_055683.3). |
| Immunogen Sequence: | SMSEDVRQRHRYLSHLPLTC EFSICELALQPPVVSKETLE MFSDDIEKRKRQRQKKAREE RRRERRIEIEENKKQGKYPE VHIPLENLQQFPAFNSYTCS SDSALGPTSTEGHGALSISP LSRSPGSHADFLLTPLSPTA SQGSPSFCVGSLEEDSPFPS FAQMLRVGKAKADVWPKTAP KKDENSLVPPAPVDSDGESD NSDRVPVPSFQNSFSQAIEA AFMKLDTPATSDPLSEEKG |
| Function | E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling. Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome. Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation. The action of RNF10 in iRQC is counteracted by USP10. May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf10Ring Finger Protein 10 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf10 antibodyAnti-Ring Finger Protein 10 antibodyAnti-RNF10 antibodyAnti-KIAA0262 antibodyAnti-RIE2 antibody |
Information sourced from Uniprot.org