Anti-RNASEK antibody (27-77 aa) (STJ196630)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human RNK at the amino acid range 27-77
General Information
| Short Description | Rabbit polyclonal anti-Ribonuclease kappa (27-77 aa) for use in IHC and IF in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RNASEK |
| Gene ID | 440400 |
| Uniprot ID | RNK_HUMAN |
| Immunogen | Synthesized peptide derived from the human RNK at the amino acid range 27-77 |
| Immunogen Region | 27-77 aa |
| Specificity | This antibody detects endogenous levels of RNK at Human/Mouse |
Additional Info
| Function | Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate. Regulates the activity of vacuolar (H+)-ATPase (V-ATPase) which is responsible for acidifying and maintaining the pH of intracellular compartments. Required at an early stage of receptor-mediated endocytosis. (Microbial infection) Required at an early stage of both clathrin-mediated and clathrin-independent endocytic uptake of a diverse set of viruses, including dengue, West Nile, Sindbis, Rift Valley Fever, influenza, and human rhinoviruses. |
| Protein Name | Ribonuclease KappaRnase KRnase KappaV-Type Proton Atpase Subunit FV-Atpase Subunit F |
| Database Links | |
| Cellular Localisation | Endomembrane SystemMulti-Pass Membrane ProteinCytoplasmic VesicleClathrin-Coated Vesicle Membrane |
| Alternative Antibody Names | Anti-Ribonuclease Kappa antibodyAnti-Rnase K antibodyAnti-Rnase Kappa antibodyAnti-V-Type Proton Atpase Subunit F antibodyAnti-V-Atpase Subunit F antibodyAnti-RNASEK antibody |
Information sourced from Uniprot.org