| Host: | Rabbit |
| Applications: | IHC/IF |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Ribonuclease kappa (27-77 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 1:50-200IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RNASEK |
| Gene ID: | 440400 |
| Uniprot ID: | RNK_HUMAN |
| Immunogen Region: | 27-77 aa |
| Specificity: | This antibody detects endogenous levels of RNK at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human RNK at the amino acid range 27-77 |
| Function | Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate. Regulates the activity of vacuolar (H+)-ATPase (V-ATPase) which is responsible for acidifying and maintaining the pH of intracellular compartments. Required at an early stage of receptor-mediated endocytosis. (Microbial infection) Required at an early stage of both clathrin-mediated and clathrin-independent endocytic uptake of a diverse set of viruses, including dengue, West Nile, Sindbis, Rift Valley Fever, influenza, and human rhinoviruses. |
| Protein Name | Ribonuclease KappaRnase KRnase KappaV-Type Proton Atpase Subunit FV-Atpase Subunit F |
| Cellular Localisation | Endomembrane SystemMulti-Pass Membrane ProteinCytoplasmic VesicleClathrin-Coated Vesicle Membrane |
| Alternative Antibody Names | Anti-Ribonuclease Kappa antibodyAnti-Rnase K antibodyAnti-Rnase Kappa antibodyAnti-V-Type Proton Atpase Subunit F antibodyAnti-V-Atpase Subunit F antibodyAnti-RNASEK antibody |
Information sourced from Uniprot.org