| Host: | Rabbit |
| Applications: | IHC-P/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RNASE3 |
| Gene ID: | 6037 |
| Uniprot ID: | ECP_HUMAN |
| Immunogen Region: | 28-160 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-160 of human RNASE3 (NP_002926.2). |
| Immunogen Sequence: | RPPQFTRAQWFAIQHISLNP PRCTIAMRAINNYRWRCKNQ NTFLRTTFANVVNVCGNQSI RCPHNRTLNNCHRSRFRVPL LHCDLINPGAQNISNCTYAD RPGRRFYVVACDNRDPRDSP RYPVVPVHLDTTI |
| Function | Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. |
| Protein Name | Eosinophil Cationic ProteinEcpRibonuclease 3Rnase 3 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedLocated In The Matrix Of Eosinophil Large Specific GranuleWhich Are Released Following Activation By An Immune Stimulus |
| Alternative Antibody Names | Anti-Eosinophil Cationic Protein antibodyAnti-Ecp antibodyAnti-Ribonuclease 3 antibodyAnti-Rnase 3 antibodyAnti-RNASE3 antibodyAnti-ECP antibodyAnti-RNS3 antibody |
Information sourced from Uniprot.org