| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Receptor-interacting serine/threonine-protein kinase 4 (280-330 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RIPK4 |
| Uniprot ID: |
RIPK4_HUMAN |
| Immunogen Region: |
280-330 aa |
| Specificity: |
This antibody detects endogenous levels of RIPK4 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human RIPK4 at the amino acid range 280-330 |
| Post Translational Modifications | May be phosphorylated by MAP3K2 and MAP3K3. Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-388 and Asp-426. Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. |
| Function | Serine/threonine protein kinase. Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. |
| Protein Name | Receptor-Interacting Serine/Threonine-Protein Kinase 4Ankyrin Repeat Domain-Containing Protein 3Pkc-Delta-Interacting Protein Kinase |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Receptor-Interacting Serine/Threonine-Protein Kinase 4 antibodyAnti-Ankyrin Repeat Domain-Containing Protein 3 antibodyAnti-Pkc-Delta-Interacting Protein Kinase antibodyAnti-RIPK4 antibodyAnti-ANKRD3 antibodyAnti-DIK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
