| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Receptor-interacting serine/threonine-protein kinase 4 (280-330 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RIPK4 |
| Uniprot ID: | RIPK4_HUMAN |
| Immunogen Region: | 280-330 aa |
| Specificity: | This antibody detects endogenous levels of RIPK4 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human RIPK4 at the amino acid range 280-330 |
| Post Translational Modifications | May be phosphorylated by MAP3K2 and MAP3K3. Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-388 and Asp-426. Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. |
| Function | Serine/threonine protein kinase. Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. |
| Protein Name | Receptor-Interacting Serine/Threonine-Protein Kinase 4 Ankyrin Repeat Domain-Containing Protein 3 Pkc-Delta-Interacting Protein Kinase |
| Cellular Localisation | Cytoplasm Membrane Peripheral Membrane Protein |
| Alternative Antibody Names | Anti-Receptor-Interacting Serine/Threonine-Protein Kinase 4 antibody Anti-Ankyrin Repeat Domain-Containing Protein 3 antibody Anti-Pkc-Delta-Interacting Protein Kinase antibody Anti-RIPK4 antibody Anti-ANKRD3 antibody Anti-DIK antibody |
Information sourced from Uniprot.org