| Short Description : | Rabbit polyclonal RIPK4 (240-520) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RIPK4Uniprot ID=RIPK4_HUMAN" |
| Immunogen Region: | 240-520 |
| Immunogen Sequence: | HRPELPPVCRARPRACSHLI RLMQRCWQGDPRVRPTFQEI TSETEDLCEKPDDEVKETAH DLDVKSPPEPRSEVVPARLK RASAPTFDNDYSLSELLSQL DSGVSQAVEGPEELSRSSSE SKLPSSGSGKRLSGVSSVDS AFSSRGSLSLSFEREPSTSD LGTTDVQKKKLVDAIVSGDT SKLMKILQPQDVDLALDSGA SLLHLAVEAGQEECAKWLLL NNANPNLSNRRGSTPLHMA |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-520 of human RIPK4 (NP_065690.2). |
| Tissue Specificity | Expressed in hair follicles and skin. |
| Post Translational Modifications | May be phosphorylated by MAP3K2 and MAP3K3. Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-388 and Asp-426. Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. |
| Function | Serine/threonine protein kinase. Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. |
| Protein Name | Receptor-Interacting Serine/Threonine-Protein Kinase 4Ankyrin Repeat Domain-Containing Protein 3Pkc-Delta-Interacting Protein Kinase |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Receptor-Interacting Serine/Threonine-Protein Kinase 4 antibodyAnti-Ankyrin Repeat Domain-Containing Protein 3 antibodyAnti-Pkc-Delta-Interacting Protein Kinase antibodyAnti-RIPK4 antibodyAnti-ANKRD3 antibodyAnti-DIK antibody |
Information sourced from Uniprot.org
