Anti-RIP antibody [PT0147R] (STJA0039721)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgGk
General Information
| Short Description | Rabbit monoclonal anti-Rpa-Interacting Protein for use in WB, IHC, IF and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PT0147R |
| Isotype | IgGk |
| Conjugation | Unconjugated |
| Purification | Protein A |
| Dilution Range | IHC 1:200-1000WB 1:1000-5000IF 1:200-1000ELISA 1:5000-20000 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage Instruction | Store at-20Β°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RPAIN |
| Gene ID | 84268 |
| Uniprot ID | RIP_HUMAN |
| Specificity | Endogenous |
Additional Info
| Post Translational Modifications | Isoform 2: Sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues. Variant 'Lys-103' adds a sumoylation site and increases total sumoylation levels. |
| Function | Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism. |
| Protein Name | Rpa-Interacting ProteinHrip |
| Database Links | |
| Cellular Localisation | Isoform 1: CytoplasmNucleusIsoform 2: NucleusPml Body |
| Alternative Antibody Names | Anti-Rpa-Interacting Protein antibodyAnti-Hrip antibodyAnti-RPAIN antibodyAnti-RIP antibody |
Information sourced from Uniprot.org