| Post Translational Modifications | Isoform 2: Sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues. Variant 'Lys-103' adds a sumoylation site and increases total sumoylation levels. |
| Function | Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism. |
| Protein Name | Rpa-Interacting ProteinHrip |
| Database Links | |
| Cellular Localisation | Isoform 1: CytoplasmNucleusIsoform 2: NucleusPml Body |
| Alternative Antibody Names | Anti-Rpa-Interacting Protein antibodyAnti-Hrip antibodyAnti-RPAIN antibodyAnti-RIP antibody |
Information sourced from Uniprot.org
