| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Serine/threonine-protein kinase RIO3 (271-320 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RIOK3 |
| Gene ID: | 8780 |
| Uniprot ID: | RIOK3_HUMAN |
| Immunogen Region: | 271-320 aa |
| Specificity: | SUDD Polyclonal Antibody detects endogenous levels of SUDD protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human RIOK3 at the amino acid range 271-320 |
| Post Translational Modifications | Autophosphorylated (in vitro). |
| Function | Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA. |
| Protein Name | Serine/Threonine-Protein Kinase Rio3Rio Kinase 3Sudd Homolog |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Rio3 antibodyAnti-Rio Kinase 3 antibodyAnti-Sudd Homolog antibodyAnti-RIOK3 antibodyAnti-SUDD antibody |
Information sourced from Uniprot.org