| Host: | Rabbit |
| Applications: | WB/IHC-P/IP/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S2MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RING1 |
| Gene ID: | 6015 |
| Uniprot ID: | RING1_HUMAN |
| Immunogen Region: | 100-200 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RING1A A (Q06587). |
| Immunogen Sequence: | DPNFDALISKIYPSREEYEA HQDRVLIRLSRLHNQQALSS SIEEGLRMQAMHRAQRVRRP IPGSDQTTTMSGGEGEPGEG EGDGEDVSSDSAPDSAPGPA P |
| Function | Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. |
| Protein Name | E3 Ubiquitin-Protein Ligase Ring1Polycomb Complex Protein Ring1Ring Finger Protein 1Ring-Type E3 Ubiquitin Transferase Ring1Really Interesting New Gene 1 Protein |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-3108214Reactome: R-HSA-3899300Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4655427Reactome: R-HSA-8939243Reactome: R-HSA-8943724Reactome: R-HSA-8953750 |
| Cellular Localisation | NucleusNucleus Speckle |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Ring1 antibodyAnti-Polycomb Complex Protein Ring1 antibodyAnti-Ring Finger Protein 1 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Ring1 antibodyAnti-Really Interesting New Gene 1 Protein antibodyAnti-RING1 antibodyAnti-RING1A antibodyAnti-RNF1 antibody |
Information sourced from Uniprot.org