| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RIC8A (362-531) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RIC8A |
| Gene ID: |
60626 |
| Uniprot ID: |
RIC8A_HUMAN |
| Immunogen Region: |
362-531 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 362-531 of human RIC8A (NP_001273063.1). |
| Immunogen Sequence: |
DVRTRPEVGEMLRNKLVRLM THLDTDVKRVAAEFLFVLCS ESVPRFIKYTGYGNAAGLLA ARGLMAGGRPEGQYSEDEDT DTDEYKEAKASINPVTGRVE EKPPNPMEGMTEEQKEHEAM KLVTMFDKLSRNRVIQPMGM SPRGHLTSLQDAMCETMEQQ LSSDPDSDPD |
| Function | Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. |
| Protein Name | Synembryn-AProtein Ric-8a |
| Cellular Localisation | CytoplasmCell MembraneColocalizes With Rgs14 In Ca2 Hippocampal NeuronsColocalizes With Gnai1 And Rgs14 At The Plasma Membrane |
| Alternative Antibody Names | Anti-Synembryn-A antibodyAnti-Protein Ric-8a antibodyAnti-RIC8A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
