| Host: |
Mouse |
| Applications: |
ELISA/WB/IHC, IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Ribonuclease 7 is suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
4C4 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
PBS pH 7.4, with 0.1% sodium azide |
| Purification: |
Protein G purification |
| Dilution Range: |
ELISA 0.05 to 0.1 µg/ml; WB 0.5 to 1 µg/ml; IF 0.2 to 20 µg/ml; IHC 2 to 20 µg/ml; Monoclonal antibody optimal dilution has to be established practically for each antigen and assay format |
| Storage Instruction: |
Store at-20 or-70 °C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles as product degradation may result |
| Gene Symbol: |
RNASE7 |
| Gene ID: |
84659 |
| Uniprot ID: |
RNAS7_HUMAN |
| Specificity: |
Human Ribonuclease 7 |
| Immunogen: |
Recombinant human RNase 7 protein produced by CHO-based proprietary suspension cell line. Human Ribonuclease 7 |
| Tissue Specificity | Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level). Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut. Expressed in liver, kidney, skeletal muscle and heart. |
| Function | Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms including uropathogenic E.coli (UPEC), and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Causes loss of bacterial membrane integrity. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. |
| Protein Name | Ribonuclease 7Rnase 7Skin-Derived Antimicrobial Protein 2Sap-2 |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedDetected In Urine |
| Alternative Antibody Names | Anti-Ribonuclease 7 antibodyAnti-Rnase 7 antibodyAnti-Skin-Derived Antimicrobial Protein 2 antibodyAnti-Sap-2 antibodyAnti-RNASE7 antibodyAnti-UNQ2516 antibodyAnti-PRO6006 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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