| Tissue Specificity | Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta. |
| Post Translational Modifications | Ubiquitinated. 'Lys-48'-linked ubiquitination at Lys-177 and Lys-248 by the ECS(RAB40A) complex leading to its degradation. Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation. |
| Function | Binds to and activates protein kinase PAK1. Plays a role in the regulation of cell morphology, cytoskeletal organization and focal adhesion assembly during cell migration. Also stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. |
| Protein Name | Rho-Related Gtp-Binding Protein RhouCdc42-Like Gtpase 1Gtp-Binding Protein-Like 1Rho Gtpase-Like Protein ArhuRyu GtpaseWnt-1 Responsive Cdc42 Homolog 1Wrch-1 |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-9013420 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideGolgi Apparatus MembraneCell JunctionFocal AdhesionCell ProjectionPodosomeLocalizes To Podosomes In Src-Transformed Cells |
| Alternative Antibody Names | Anti-Rho-Related Gtp-Binding Protein Rhou antibodyAnti-Cdc42-Like Gtpase 1 antibodyAnti-Gtp-Binding Protein-Like 1 antibodyAnti-Rho Gtpase-Like Protein Arhu antibodyAnti-Ryu Gtpase antibodyAnti-Wnt-1 Responsive Cdc42 Homolog 1 antibodyAnti-Wrch-1 antibodyAnti-RHOU antibodyAnti-ARHU antibodyAnti-CDC42L1 antibodyAnti-G28K antibodyAnti-WRCH1 antibodyAnti-SB128 antibody |
Information sourced from Uniprot.org
