| Host: | Guinea Pig |
| Applications: | IHC/WB |
| Reactivity: | Human/Mouse/Rat/Marmoset |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Guinea Pig polyclonal antibody anti-Rhodopsin is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised |
| Purification: | Affinity purification |
| Dilution Range: | IHC, WB. A dilution of 1:2000 is recommended for IHC-P and WB. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | Rho |
| Gene ID: | 24717 |
| Uniprot ID: | OPSD_RAT |
| Specificity: | Specific for Rhodopsin. |
| Immunogen: | A synthetic peptide from human Rhodopsin conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse and rat. |
| Function | Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. |
| Protein Name | Rhodopsin |
| Database Links | Reactome: R-RNO-2453902 Reactome: -RNO-2485179 Reactome: -RNO-2514859 Reactome: -RNO-418594 Reactome: -RNO-419771 Reactome: -RNO-5620916 |
| Cellular Localisation | Membrane Multi-Pass Membrane Protein Cell Projection Cilium Photoreceptor Outer Segment Synthesized In The Inner Segment (Is) Of Rod Photoreceptor Cells Before Vectorial Transport To Disk Membranes In The Rod Outer Segment (Os) Photosensory Cilia |
| Alternative Antibody Names | Anti-Rhodopsin antibody Anti-Rho antibody |
Information sourced from Uniprot.org
