Anti-RHBDF1 antibody (200-400) (STJ119793)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RHBDF1 (200-400) antibody for use in WB, IF, ICC and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RHBDF1 |
| Gene ID | 64285 |
| Uniprot ID | RHDF1_HUMAN |
| Immunogen Region | 200-400 |
| Immunogen Sequence | HRLPRRRKRESVAKMSFRAA AALMKGRSVRDGTFRRAQRR SFTPASFLEEDTTDFPDELD TSFFAREGILHEELSTYPDE VFESPSEAALKDWEKAPEQA DLTGGALDRSELERSHLMLP LERGWRKQKEGAAAPQPKVR LRQEVVSTAGPRRGQRIAVP VRKLFAREKRPYGLGMVGRL TNRTYRKRIDSFVKRQIEDM D |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 200-400 of human RHBDF1 (NP_071895.3). |
Additional Info
| Tissue Specificity | Highly expressed in cerebellum, cerebrum, heart, skeletal muscle, placenta, pancreatic islet and testis. Detected at lower levels in colon, kidney, small intestine and lung. |
| Post Translational Modifications | N-glycosylated. |
| Function | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. |
| Protein Name | Inactive Rhomboid Protein 1Irhom1Epidermal Growth Factor Receptor-Related ProteinRhomboid 5 Homolog 1Rhomboid Family Member 1P100hrho |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembranePredominantly Localized In The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Inactive Rhomboid Protein 1 antibodyAnti-Irhom1 antibodyAnti-Epidermal Growth Factor Receptor-Related Protein antibodyAnti-Rhomboid 5 Homolog 1 antibodyAnti-Rhomboid Family Member 1 antibodyAnti-P100hrho antibodyAnti-RHBDF1 antibodyAnti-C16orf8 antibodyAnti-DIST1 antibodyAnti-IRHOM1 antibody |
Information sourced from Uniprot.org