Anti-RGS7 antibody (155-204 aa) (STJ95441)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human RGS7 at the amino acid range 155-204
General Information
| Short Description | Rabbit polyclonal anti-Regulator of G-protein signaling 7 (155-204 aa) for use in WB, ELISA and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RGS7 |
| Gene ID | 6000 |
| Uniprot ID | RGS7_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human RGS7 at the amino acid range 155-204 |
| Immunogen Region | 155-204 aa |
| Specificity | RGS7 Polyclonal Antibody detects endogenous levels of RGS7 protein. |
Additional Info
| Function | GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form. May play a role in synaptic vesicle exocytosis (Probable). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. |
| Protein Name | Regulator Of G-Protein Signaling 7Rgs7 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-6814122 |
| Cellular Localisation | CytoplasmCytosolCell MembraneMembranePeripheral Membrane ProteinCytoplasmic SideInteraction With Pkd1 Promotes Location At The Cell MembraneInteraction With Rgs7bp Promotes Location At The Cell Membrane |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 7 antibodyAnti-Rgs7 antibodyAnti-RGS7 antibody |
Information sourced from Uniprot.org