Anti-RGS7 antibody (1-300) (STJ28803)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RGS7 (1-300) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RGS7 |
| Gene ID | 6000 |
| Uniprot ID | RGS7_HUMAN |
| Immunogen Region | 1-300 |
| Immunogen Sequence | MAQGNNYGQTSNGVADESPN MLVYRKMEDVIARMQDEKNG IPIRTVKSFLSKIPSVFSGS DIVQWLIKNLTIEDPVEALH LGTLMAAHGYFFPISDHVLT LKDDGTFYRFQTPYFWPSNC WEPENTDYAVYLCKRTMQNK ARLELADYEAESLARLQRAF ARKWEFIFMQAEAQAKVDKK RDKIERKILDSQERAFWDVH RPVPGCVNTTEVDIKKSSRM RNPHKTRKSVYGLQNDIRS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human RGS7 (NP_002915.3). |
Additional Info
| Post Translational Modifications | Palmitoylated. Ubiquitinated, leading to rapid proteasomal degradation. Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity. |
| Function | GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form. May play a role in synaptic vesicle exocytosis (Probable). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. |
| Protein Name | Regulator Of G-Protein Signaling 7Rgs7 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-6814122 |
| Cellular Localisation | CytoplasmCytosolCell MembraneMembranePeripheral Membrane ProteinCytoplasmic SideInteraction With Pkd1 Promotes Location At The Cell MembraneInteraction With Rgs7bp Promotes Location At The Cell Membrane |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 7 antibodyAnti-Rgs7 antibodyAnti-RGS7 antibody |
Information sourced from Uniprot.org