| Short Description : | Rabbit polyclonal RGS4 (1-100) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RGS4 |
| Gene ID: | 5999 |
| Uniprot ID: | RGS4_HUMAN |
| Immunogen Region: | 1-100 |
| Immunogen Sequence: | MCKGLAGLPASCLRSAKDMK HRLGFLLQKSDSCEHNSSHN KKDKVVICQRVSQEEVKKWA ESLENLISHECGLAAFKAFL KSEYSEENIDFWISCEEYKK |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RGS4 (NP_005604.1). |
| Tissue Specificity | Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum. |
| Post Translational Modifications | Palmitoylated on Cys-2 and/or Cys-12. Phosphorylated by cyclic GMP-dependent protein kinase. |
| Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. |
| Protein Name | Regulator Of G-Protein Signaling 4Rgp4Rgs4 |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-418594Reactome: R-HSA-418597 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 4 antibodyAnti-Rgp4 antibodyAnti-Rgs4 antibodyAnti-RGS4 antibody |
Information sourced from Uniprot.org
