| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RGS10 |
| Gene ID: | 6001 |
| Uniprot ID: | RGS10_HUMAN |
| Immunogen Region: | 1-181 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human RGS10 (NP_001005339.1). |
| Immunogen Sequence: | MFNRAVSRLSRKRPPSDIHD SDGSSSSSHQSLKSTAKWAA SLENLLEDPEGVKRFREFLK KEFSEENVLFWLACEDFKKM QDKTQMQEKAKEIYMTFLSS KASSQVNVEGQSRLNEKILE EPHPLMFQKLQDQIFNLMKY DSYSRFLKSDLFLKHKRTEE EEEDLPDAQTAAKRASRIYN T |
| Function | Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein. |
| Protein Name | Regulator Of G-Protein Signaling 10Rgs10 |
| Database Links | Reactome: R-HSA-418594 |
| Cellular Localisation | Isoform 1: CytoplasmCytosolNucleusForskolin Treatment Promotes Phosphorylation And Translocation To The Nucleus |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 10 antibodyAnti-Rgs10 antibodyAnti-RGS10 antibody |
Information sourced from Uniprot.org