| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RGMA (101-450) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RGMA |
| Gene ID: |
56963 |
| Uniprot ID: |
RGMA_HUMAN |
| Immunogen Region: |
101-450 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 101-450 of human RGMA (NP_064596.2). |
| Immunogen Sequence: |
SAVHGIEDLMSQHNCSKDGP TSQPRLRTLPPAGDSQERSD SPEICHYEKSFHKHSATPNY THCGLFGDPHLRTFTDRFQT CKVQGAWPLIDNNYLNVQVT NTPVLPGSAATATSKLTIIF KNFQECVDQKVYQAEMDELP AAFVDGSKNGGDKHGANSLK ITEKVSGQHVEIQAKYIGTT IVVRQVGRYLTFAVRMPEEV VNAVEDWDSQGLYLCLRGCP LNQQIDFQAFHTNAEGTGA |
| Post Translational Modifications | Autocatalytically cleaved at low pH.the two chains remain linked via two disulfide bonds. |
| Function | Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. |
| Protein Name | Repulsive Guidance Molecule ARgm Domain Family Member A |
| Database Links | Reactome: R-HSA-373752 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Repulsive Guidance Molecule A antibodyAnti-Rgm Domain Family Member A antibodyAnti-RGMA antibodyAnti-RGM antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
