| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RGCC (40-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RGCC |
| Gene ID: |
28984 |
| Uniprot ID: |
RGCC_HUMAN |
| Immunogen Region: |
40-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 40-100 of human RGCC (NP_054778.2). |
| Immunogen Sequence: |
ADFASPFHERHFHYEEHLER MKRRSSASVSDSSGFSDSES ADSLYRNSFSFSDEKLNSPT D |
| Tissue Specificity | Detected in brain, heart and liver (at protein level). Highly expressed in liver, skeletal muscle, kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial cells. Overexpressed in colon, breast, prostate, bladder, lung, and ovarian cancer tissues. |
| Function | Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. |
| Protein Name | Regulator Of Cell Cycle RgccResponse Gene To Complement 32 ProteinRgc-32 |
| Database Links | Reactome: R-HSA-6804115 |
| Cellular Localisation | CytoplasmNucleusCytoskeletonMicrotubule Organizing CenterCentrosomeCytoplasmic In Unstimulated CellsNuclear After Activation By ComplementAssociated With The Centrosome During Prometaphase And Metaphase |
| Alternative Antibody Names | Anti-Regulator Of Cell Cycle Rgcc antibodyAnti-Response Gene To Complement 32 Protein antibodyAnti-Rgc-32 antibodyAnti-RGCC antibodyAnti-C13orf15 antibodyAnti-RGC32 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
