| Tissue Specificity | Highly expressed in the heart and at lower levels in the lymph nodes, brain, lung, liver, spleen and thymus. |
| Function | 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development. Isoform 3: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. |
| Protein Name | Oligoribonuclease - MitochondrialRna Exonuclease 2 HomologSmall Fragment Nuclease |
| Database Links | Reactome: R-HSA-9836573 |
| Cellular Localisation | Mitochondrion Intermembrane SpaceMitochondrion MatrixMitochondrionCytoplasmNucleusIsoform 3: Cytoplasm |
| Alternative Antibody Names | Anti-Oligoribonuclease - Mitochondrial antibodyAnti-Rna Exonuclease 2 Homolog antibodyAnti-Small Fragment Nuclease antibodyAnti-REXO2 antibodyAnti-SFN antibodyAnti-SMFN antibodyAnti-CGI-114 antibody |
Information sourced from Uniprot.org
