| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
RNLS |
| Gene ID: |
55328 |
| Uniprot ID: |
RNLS_HUMAN |
| Immunogen Region: |
31-342 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 31-342 of human Renalase (NP_001026879.2). |
| Immunogen Sequence: |
AVWDKAEDSGGRMTTACSPH NPQCTADLGAQYITCTPHYA KKHQRFYDELLAYGVLRPLS SPIEGMVMKEGDCNFVAPQG ISSIIKHYLKESGAEVYFRH RVTQINLRDDKWEVSKQTGS PEQFDLIVLTMPVPEILQLQ GDITTLISECQRQQLEAVSY SSRYALGLFYEAGTKIDVPW AGQYITSNPCIRFVSIDNKK RNIESSEIGPSLVIHTTVPF GVTYLEHSIEDVQELVFQQ |
| Tissue Specificity | Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. |
| Function | Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. |
| Protein Name | RenalaseMonoamine Oxidase-CMao-C |
| Database Links | Reactome: R-HSA-197264 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Renalase antibodyAnti-Monoamine Oxidase-C antibodyAnti-Mao-C antibodyAnti-RNLS antibodyAnti-C10orf59 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
