| Function | 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis. |
| Protein Name | 3'-5' Rna Helicase Ythdc2Keen To Exit Meiosis Leaving Testes Under-Populated ProteinKetuYth Domain-Containing Protein C2Mythdc2 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-3'-5' Rna Helicase Ythdc2 antibodyAnti-Keen To Exit Meiosis Leaving Testes Under-Populated Protein antibodyAnti-Ketu antibodyAnti-Yth Domain-Containing Protein C2 antibodyAnti-Mythdc2 antibodyAnti-Ythdc2 antibody |
Information sourced from Uniprot.org
![Immunoprecipitation of YTHDC2 in 200 µg extracts from 293T cells using 0. 5 µg [KD Validated] YTHDC2 Rabbit polyclonal antibody (STJ11105298). Western blot analysis was performed using [KD Validated] YTHDC2 Rabbit polyclonal antibody (STJ11105298) at 1:1000 dilution.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/177942/369971/STJ11105298_1__81591.1713135883.jpg?c=1 "Immunoprecipitation of YTHDC2 in 200 µg extracts from 293T cells using 0. 5 µg [KD Validated] YTHDC2 Rabbit polyclonal antibody (STJ11105298). Western blot analysis was performed using [KD Validated] YTHDC2 Rabbit polyclonal antibody (STJ11105298) at 1:1000 dilution.")