Anti-Recombinant-TMEM119, OBIF antibody (113-280 Cyt C-Term) [L128/43] (STJA0040534)
SPECIFICATIONS
ClonalityMonoclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenFusion protein amino acids 113-280 (cytoplasmic C-terminus) of mouse Tmem119
General Information
| Short Description | Chicken monoclonal anti-Recombinant-TMEM119, OBIF (113-280 Cyt C-Term) for use in ELISA, ICC, IHC and WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/ICC/IHC/WB |
| Host | Chicken |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | L128/43 |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by affinity chromatography |
| Formulation | 1X PBS, 0.05% Sodium Azide pH 7.4 |
| Storage Instruction | Aliquot and store at ≤-20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap. |
Target Information
| Gene Symbol | Tmem119 |
| Gene ID | 231633 |
| Uniprot ID | TM119_MOUSE |
| Immunogen | Fusion protein amino acids 113-280 (cytoplasmic C-terminus) of mouse Tmem119 |
| Immunogen Region | 113-280 Cyt C-Term |
| Immunogen Sequence | Mouse |
| Specificity | No cross-reactivity reported |
Additional Info
| Tissue Specificity | Expressed in spermatocytes and spermatids in the developing testis (at protein level). Expressed in the brain, heart, lung, spleen, skeletal muscle, ovary, testis and epididymis. Predominantly expressed in osteoblasts. |
| Function | Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts. May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4 which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation. |
| Protein Name | Transmembrane Protein 119Osteoblast Induction FactorObif |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmEndoplasmic Reticulum MembraneSecreted |
| Alternative Antibody Names | Anti-Transmembrane Protein 119 antibodyAnti-Osteoblast Induction Factor antibodyAnti-Obif antibodyAnti-Tmem119 antibody |
Information sourced from Uniprot.org