Anti-Recombinant-TEAD1/2/3/4 antibody [RM1T55] (STJA0024336)

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STJA0024336
£309.50 - £472.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Transcriptional Enhancer Factor Tef-1 is suitable for use in Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1T55
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: TEAD1
Gene ID: 7003
Uniprot ID: TEAD1_HUMAN
Post Translational Modifications Lactylation by AARS1 promotes nuclear localization and stabilization of YAP1, leading to increased Hippo signaling pathway. Delactylated by SIRT1.
Function Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
Protein Name Transcriptional Enhancer Factor Tef-1
Ntef-1
Protein Gt-Iic
Tea Domain Family Member 1
Tead-1
Transcription Factor 13
Tcf-13
Database Links Reactome: R-HSA-2032785
Reactome: R-HSA-8951671
Reactome: R-HSA-9619665
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Transcriptional Enhancer Factor Tef-1 antibody
Anti-Ntef-1 antibody
Anti-Protein Gt-Iic antibody
Anti-Tea Domain Family Member 1 antibody
Anti-Tead-1 antibody
Anti-Transcription Factor 13 antibody
Anti-Tcf-13 antibody
Anti-TEAD1 antibody
Anti-TCF13 antibody
Anti-TEF1 antibody

Information sourced from Uniprot.org