Anti-Recombinant-SUZ12 antibody [RM2F88] (STJA0025557)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Polycomb Protein Suz12 for use in IP and WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2F88 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IP: 1:20, WB: 1:500-1:1000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | SUZ12 |
| Gene ID | 23512 |
| Uniprot ID | SUZ12_HUMAN |
Additional Info
| Post Translational Modifications | Sumoylated, probably by PIAS2. |
| Function | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. |
| Protein Name | Polycomb Protein Suz12Chromatin Precipitated E2f Target 9 ProteinChet 9 ProteinJoined To Jazf1 ProteinSuppressor Of Zeste 12 Protein Homolog |
| Database Links | Reactome: R-HSA-212300Reactome: R-HSA-2559580Reactome: R-HSA-3214841Reactome: R-HSA-4551638Reactome: R-HSA-5617472Reactome: R-HSA-8943724Reactome: R-HSA-8953750Reactome: R-HSA-9609690Reactome: R-HSA-9710421 |
| Cellular Localisation | NucleusLocalizes To Chromatin As Part Of The Prc2 Complex |
| Alternative Antibody Names | Anti-Polycomb Protein Suz12 antibodyAnti-Chromatin Precipitated E2f Target 9 Protein antibodyAnti-Chet 9 Protein antibodyAnti-Joined To Jazf1 Protein antibodyAnti-Suppressor Of Zeste 12 Protein Homolog antibodyAnti-SUZ12 antibodyAnti-CHET9 antibodyAnti-JJAZ1 antibodyAnti-KIAA0160 antibody |
Information sourced from Uniprot.org