| Post Translational Modifications | In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. |
| Function | Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. |
| Protein Name | Small Ubiquitin-Related Modifier 4Sumo-4Small Ubiquitin-Like Protein 4 |
| Alternative Antibody Names | Anti-Small Ubiquitin-Related Modifier 4 antibodyAnti-Sumo-4 antibodyAnti-Small Ubiquitin-Like Protein 4 antibodyAnti-SUMO4 antibodyAnti-SMT3H4 antibody |
Information sourced from Uniprot.org
