| Function | Mediates the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across cell membranes. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Probably involved in fatty acid transport across the blood barrier. Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones. |
| Protein Name | Long-Chain Fatty Acid Transport Protein 4Fatp-4Fatty Acid Transport Protein 4Arachidonate--Coa LigaseLong-Chain-Fatty-Acid--Coa LigaseSolute Carrier Family 27 Member 4Very Long-Chain Acyl-Coa Synthetase 4Acsvl4 |
| Database Links | Reactome: R-HSA-5619108Reactome: R-HSA-804914 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Long-Chain Fatty Acid Transport Protein 4 antibodyAnti-Fatp-4 antibodyAnti-Fatty Acid Transport Protein 4 antibodyAnti-Arachidonate--Coa Ligase antibodyAnti-Long-Chain-Fatty-Acid--Coa Ligase antibodyAnti-Solute Carrier Family 27 Member 4 antibodyAnti-Very Long-Chain Acyl-Coa Synthetase 4 antibodyAnti-Acsvl4 antibodyAnti-SLC27A4 antibodyAnti-ACSVL4 antibodyAnti-FATP4 antibody |
Information sourced from Uniprot.org
