Anti-Recombinant-SDCBP antibody [RM1C99] (STJA0022895)

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STJA0022895
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Host: Rabbit
Applications: FC/IF/IHC/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Syntenin-1 is suitable for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1C99
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: FCM: 1:20-1:100
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: SDCBP
Gene ID: 6386
Uniprot ID: SDCB1_HUMAN
Post Translational Modifications Phosphorylated on tyrosine residues.
Function Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
Protein Name Syntenin-1
Melanoma Differentiation-Associated Protein 9
Mda-9
Pro-Tgf-Alpha Cytoplasmic Domain-Interacting Protein 18
Tacip18
Scaffold Protein Pbp1
Syndecan-Binding Protein 1
Database Links Reactome: R-HSA-3928664
Reactome: R-HSA-447043
Reactome: R-HSA-5213460
Reactome: R-HSA-5675482
Reactome: R-HSA-6798695
Cellular Localisation Cell Junction
Focal Adhesion
Adherens Junction
Cell Membrane
Peripheral Membrane Protein
Endoplasmic Reticulum Membrane
Nucleus
Melanosome
Cytoplasm
Cytosol
Cytoskeleton
Secreted
Extracellular Exosome
Membrane Raft
Mainly Membrane-Associated
Localized To Adherens Junctions
Focal Adhesions And Endoplasmic Reticulum
Colocalized With Actin Stress Fibers
Also Found In The Nucleus
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Associated To The Plasma Membrane In The Presence Of Fzd7 And Phosphatidylinositol 4
5-Bisphosphate (Pip2)
Alternative Antibody Names Anti-Syntenin-1 antibody
Anti-Melanoma Differentiation-Associated Protein 9 antibody
Anti-Mda-9 antibody
Anti-Pro-Tgf-Alpha Cytoplasmic Domain-Interacting Protein 18 antibody
Anti-Tacip18 antibody
Anti-Scaffold Protein Pbp1 antibody
Anti-Syndecan-Binding Protein 1 antibody
Anti-SDCBP antibody
Anti-MDA9 antibody
Anti-SYCL antibody

Information sourced from Uniprot.org