Anti-Recombinant-RXRA antibody [RM1RM31] (STJA0024114)

SKU:
STJA0024114
£309.50 - £472.50
Free Shipping
Processing The item has been added

Host: Rabbit
Applications: IF/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Retinoic Acid Receptor Rxr-Alpha is suitable for use in Immunofluorescence, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1RM31
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IF: 1:50-1:200
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: RXRA
Gene ID: 6256
Uniprot ID: RXRA_HUMAN
Post Translational Modifications Acetylated by EP300.acetylation enhances DNA binding and transcriptional activity. Phosphorylated on serine and threonine residues mainly in the N-terminal modulating domain. Constitutively phosphorylated on Ser-21 in the presence or absence of ligand. Under stress conditions, hyperphosphorylated by activated JNK on Ser-56, Ser-70, Thr-82 and Ser-260. Phosphorylated on Ser-27, in vitro, by PKA. This phosphorylation is required for repression of cAMP-mediated transcriptional activity of RARA. Ubiquitinated by UBR5, leading to its degradation: UBR5 specifically recognizes and binds ligand-bound RXRA when it is not associated with coactivators (NCOAs). In presence of NCOAs, the UBR5-degron is not accessible, preventing its ubiquitination and degradation. Sumoylation negatively regulates transcriptional activity. Desumoylated specifically by SENP6.
Function Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription. The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation. Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA. The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells. Acts as an enhancer of RARA binding to RARE DNA element. May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1. Promotes myelin debris phagocytosis and remyelination by macrophages. Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes. Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence.
Protein Name Retinoic Acid Receptor Rxr-Alpha
Nuclear Receptor Subfamily 2 Group B Member 1
Retinoid X Receptor Alpha
Database Links Reactome: R-HSA-1368082
Reactome: R-HSA-1368108
Reactome: R-HSA-159418
Reactome: R-HSA-192105
Reactome: R-HSA-193368
Reactome: R-HSA-193807
Reactome: R-HSA-1989781
Reactome: R-HSA-200425
Reactome: R-HSA-211976
Reactome: R-HSA-2151201
Reactome: R-HSA-2426168
Reactome: R-HSA-381340
Reactome: R-HSA-383280
Reactome: R-HSA-400206
Reactome: R-HSA-400253
Reactome: R-HSA-4090294
Reactome: R-HSA-5362517
Reactome: R-HSA-5617472
Reactome: R-HSA-9029558
Reactome: R-HSA-9029569
Reactome: R-HSA-9031525
Reactome: R-HSA-9031528
Reactome: R-HSA-9616222
Reactome: R-HSA-9623433
Reactome: R-HSA-9632974
Reactome: R-HSA-9707564
Reactome: R-HSA-9707616
Reactome: R-HSA-9839394
Reactome: R-HSA-9844594
Cellular Localisation Nucleus
Cytoplasm
Mitochondrion
Localization To The Nucleus Is Enhanced By Vitamin D3
Nuclear Localization May Be Enhanced By The Interaction With Heterodimerization Partner Vdr
Translocation To The Mitochondrion Upon Interaction With Nr4a1
Increased Nuclear Localization Upon Pulsatile Shear Stress
Alternative Antibody Names Anti-Retinoic Acid Receptor Rxr-Alpha antibody
Anti-Nuclear Receptor Subfamily 2 Group B Member 1 antibody
Anti-Retinoid X Receptor Alpha antibody
Anti-RXRA antibody
Anti-NR2B1 antibody

Information sourced from Uniprot.org