Anti-Recombinant-RPS6KA2 antibody [RM2G25] (STJA0025593)

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STJA0025593
£309.50 - £472.50
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Host: Rabbit
Applications: IF/IHC/IP/WB
Reactivity: Human/Hamster
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Ribosomal Protein S6 Kinase Alpha-2 is suitable for use in Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2G25
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: RPS6KA2
Gene ID: 6196
Uniprot ID: KS6A2_HUMAN
Post Translational Modifications Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1. N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
Function Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Protein Name Ribosomal Protein S6 Kinase Alpha-2
S6k-Alpha-2
90 Kda Ribosomal Protein S6 Kinase 2
P90-Rsk 2
P90rsk2
Map Kinase-Activated Protein Kinase 1c
Mapk-Activated Protein Kinase 1c
Mapkap Kinase 1c
Mapkapk-1c
Ribosomal S6 Kinase 3
Rsk-3
Pp90rsk3
Database Links Reactome: R-HSA-198753
Reactome: R-HSA-199920
Reactome: R-HSA-2559582
Reactome: R-HSA-437239
Reactome: R-HSA-442742
Reactome: R-HSA-444257
Reactome: R-HSA-881907
Cellular Localisation Nucleus
Cytoplasm
Alternative Antibody Names Anti-Ribosomal Protein S6 Kinase Alpha-2 antibody
Anti-S6k-Alpha-2 antibody
Anti-90 Kda Ribosomal Protein S6 Kinase 2 antibody
Anti-P90-Rsk 2 antibody
Anti-P90rsk2 antibody
Anti-Map Kinase-Activated Protein Kinase 1c antibody
Anti-Mapk-Activated Protein Kinase 1c antibody
Anti-Mapkap Kinase 1c antibody
Anti-Mapkapk-1c antibody
Anti-Ribosomal S6 Kinase 3 antibody
Anti-Rsk-3 antibody
Anti-Pp90rsk3 antibody
Anti-RPS6KA2 antibody
Anti-MAPKAPK1C antibody
Anti-RSK3 antibody

Information sourced from Uniprot.org