Anti-Recombinant-RNF40 antibody [RM1F08] (STJA0023101)

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STJA0023101
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Host: Rabbit
Applications: IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-E3 Ubiquitin-Protein Ligase Bre1b is suitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1F08
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IHC: 1:100-1:200
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: RNF40
Gene ID: 9810
Uniprot ID: BRE1B_HUMAN
Function Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B.reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50.
Protein Name E3 Ubiquitin-Protein Ligase Bre1b
Bre1-B
95 Kda Retinoblastoma-Associated Protein
Rbp95
Ring Finger Protein 40
Ring-Type E3 Ubiquitin Transferase Bre1b
Database Links Reactome: R-HSA-8866654
Cellular Localisation Nucleus
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Bre1b antibody
Anti-Bre1-B antibody
Anti-95 Kda Retinoblastoma-Associated Protein antibody
Anti-Rbp95 antibody
Anti-Ring Finger Protein 40 antibody
Anti-Ring-Type E3 Ubiquitin Transferase Bre1b antibody
Anti-RNF40 antibody
Anti-BRE1B antibody
Anti-KIAA0661 antibody

Information sourced from Uniprot.org

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