Anti-Recombinant-RNASEL antibody [RM2C75] (STJA0025247)

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STJA0025247
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-2-5a-Dependent Ribonuclease is suitable for use in Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2C75
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: RNASEL
Gene ID: 6041
Uniprot ID: RN5A_HUMAN
Function Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis. Might play a central role in the regulation of mRNA turnover. Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.
Protein Name 2-5a-Dependent Ribonuclease
2-5a-Dependent Rnase
Ribonuclease 4
Ribonuclease L
Rnase L
Database Links Reactome: R-HSA-8983711
Reactome: R-HSA-909733
Cellular Localisation Cytoplasm
Mitochondrion
Alternative Antibody Names Anti-2-5a-Dependent Ribonuclease antibody
Anti-2-5a-Dependent Rnase antibody
Anti-Ribonuclease 4 antibody
Anti-Ribonuclease L antibody
Anti-Rnase L antibody
Anti-RNASEL antibody
Anti-RNS4 antibody

Information sourced from Uniprot.org