| Post Translational Modifications | Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus. Isoform 2 is sumoylated with SUMO2 and SUMO3. |
| Function | Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. Isoform 2 binds to double-stranded DNA. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Nima-Interacting 4Parvulin-14Par14Hpar14Parvulin-17Par17Hpar17Peptidyl-Prolyl Cis-Trans Isomerase Pin4Ppiase Pin4Peptidyl-Prolyl Cis/Trans Isomerase EpvhHepvhRotamase Pin4 |
| Database Links | |
| Cellular Localisation | Isoform 1: NucleusNucleolusCytoplasmCytoskeletonSpindleColocalizes In The Nucleolus During Interphase And On The Spindle Apparatus During Mitosis With Npm1Isoform 2: MitochondrionMitochondrion MatrixImported In A Time- And Membrane Potential-Dependent Manner To The Mitochondrial MatrixBut Without Concomitant Processing Of The ProteinDirected To Mitochondria By A Novel N-Terminal Domain That Functions As A Non-Cleavable Mitochondrial Targeting Peptide |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase Nima-Interacting 4 antibodyAnti-Parvulin-14 antibodyAnti-Par14 antibodyAnti-Hpar14 antibodyAnti-Parvulin-17 antibodyAnti-Par17 antibodyAnti-Hpar17 antibodyAnti-Peptidyl-Prolyl Cis-Trans Isomerase Pin4 antibodyAnti-Ppiase Pin4 antibodyAnti-Peptidyl-Prolyl Cis/Trans Isomerase Epvh antibodyAnti-Hepvh antibodyAnti-Rotamase Pin4 antibodyAnti-PIN4 antibody |
Information sourced from Uniprot.org
