| Function | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF). |
| Protein Name | Phosphatidylinositol-Binding Clathrin Assembly ProteinClathrin Assembly Lymphoid Myeloid Leukemia Protein |
| Database Links | Reactome: R-HSA-432722Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-9696264 |
| Cellular Localisation | Cell MembraneMembraneClathrin-Coated PitGolgi ApparatusCytoplasmic VesicleClathrin-Coated VesicleNucleusColocalized With Clathrin In The Golgi AreaInteraction With Pimreg May Target Picalm To The Nucleus In Some Cells |
| Alternative Antibody Names | Anti-Phosphatidylinositol-Binding Clathrin Assembly Protein antibodyAnti-Clathrin Assembly Lymphoid Myeloid Leukemia Protein antibodyAnti-PICALM antibodyAnti-CALM antibody |
Information sourced from Uniprot.org
