Anti-Recombinant-PICALM antibody [RM2E45] (STJA0025415)

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STJA0025415
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Host: Rabbit
Applications: IF/IHC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Phosphatidylinositol-Binding Clathrin Assembly Protein is suitable for use in Immunofluorescence, Immunohistochemistry and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2E45
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: PICALM
Gene ID: 8301
Uniprot ID: PICAL_HUMAN
Function Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF).
Protein Name Phosphatidylinositol-Binding Clathrin Assembly Protein
Clathrin Assembly Lymphoid Myeloid Leukemia Protein
Database Links Reactome: R-HSA-432722
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Reactome: R-HSA-9696264
Cellular Localisation Cell Membrane
Membrane
Clathrin-Coated Pit
Golgi Apparatus
Cytoplasmic Vesicle
Clathrin-Coated Vesicle
Nucleus
Colocalized With Clathrin In The Golgi Area
Interaction With Pimreg May Target Picalm To The Nucleus In Some Cells
Alternative Antibody Names Anti-Phosphatidylinositol-Binding Clathrin Assembly Protein antibody
Anti-Clathrin Assembly Lymphoid Myeloid Leukemia Protein antibody
Anti-PICALM antibody
Anti-CALM antibody

Information sourced from Uniprot.org